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Chapter 14e Amniotic fluid embolism
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Disclaimer | Background | Pathogenesis | Prevalence | Maternal mortality / morbidity | Risk factors | Diagnosis | Presentation | Management | References | Last reviewed
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> The pathogenesis of AFE is poorly understood. The entrance of amniotic fluid into the maternal circulation, possibly under a pressure gradient, is the principal mechanism invoked in the pathogenesis of AFE. This triggers the clinical manifestations of the condition (mainly maternal cardio-respiratory collapse), but how it does so is less clear. Some have suggested that it represents an anaphylactic reaction to the fetal material, which stimulates a cascade of endogenous-immune mediators (Conde-Agudelo & Romero 2009) top
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