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  Chapter 31 Preterm prelabour rupture of the membranes (PPROM) 

Disclaimer | Introduction and definition | Associated risks of PPROM | Initial assessment | Antibiotic prophylaxis | Tocolytics | Corticosteroids | Magnesium sulphate for neuroprotection of the fetu | Counselling | Management | Home care | References | Last reviewed
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  1. Royal College of Obstetricians and Gynaecologists (RCOG).  Preterm prelabour rupture of membranes.  RCOG guideline No. 44, November 2006.  Available from URL:
  2. Kenyon S, Boulvain M, Neilson JP. Antibiotics for preterm rupture of membranes. Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD001058. DOI: 10.1002/14651858.CD001058 (Level I).  Available from URL:
  3. Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD004454. DOI:  10.1002/14651858.CD004454.pub2 (Level I).  Available form URL:
  4. Crowther CA, Harding JE. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for preventing neonatal respiratory disease. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD003935. DOI: 10.1002/14651858.CD003935.pub2 (Level I).  Available from URL:
  5. Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: CD004661. DOI:  10.1002/14651858.CD004661.pub3 (Level I).  Available from URL:
  6. The Antenatal Magnesium Sulphate for Neuroprotection Guideline Development Panel. Antenatal magnesium sulphate prior to preterm birth for neuroprotection of the fetus, infant and child: National clinical practice guidelines. Adelaide: The University of Adelaide, 2010.  ISBN Print: 978-0-86396-720-7. Available from URL:
  7. MIMS Online. MIMS Pharmaceutical Product Information. [online database] Full product information Adalat® tablets data version August 2010 [cited 2010 Aug 16].  Available: MIMS Online.  (Level I).
  8. Enkin M, Keirse MJNC, Neilson J, Crowther C, Duley L, Hodnett E, Hofmeyr J.  A guide to effective care in pregnancy and childbirth. 3rd ed. Oxford: Oxford University Press; 2000 (Level I).
  9. Ryan G, Oskamp M, Seaward PGR, Kitch T, Barrett T, Brennan B, Salenieks ME, O’Brien K. Randomized controlled trial of inpatient vs. outpatient management of PPROM. Am J Obstet Gynecol 1999; 180: S95 (Level II).
  10. Segal S, Miles A, Clothier B, Parry S, Macones G. Optimal duration of antibiotic therapy after PPROM [abstract].  Am J Obstet Gynecol 2002; 187: S72 (Level II). 


Home care | Page 12 of 13 | Last reviewed